Endocrine Abstracts

Background: Growth hormone deficiency (GHD) in children comes in different etiologies and can be either isolated or combined with other pituitary hormone deficiencies. The diversity in GHD types and the variable duration of GH therapy complicate assessments of long-term treatment outcome. We characterized GHD patients at the end of GH therapy in Belgium and Luxemburg and evaluated height and adiposity outcomes in relation to GHD type.Methods: Anthropomet...

X-linked acro-gigantism (X-LAG) is a rare novel genomic syndrome of pituitary gigantism that has a typical onset within the first year of life in children of normal or even low birth weight. X-LAG patients have a microduplications on chromosome Xq26.3 that includes a gene GPR101, which is highly upregulated in pituitary tumor tissue of affected patients. We performed a study of all 18 known X-LAG syndrome patients currently in the NICHD-University of Liège databa...